No, do not remove your cover. We recommend spot-cleaning the outer quilted layer of your Avocado Organic Latex Topper, Vegan Mattress Topper, and Eco Organic Mattress Topper. Use hot water and eco-friendly soap to dab the GOTS-certified organic cotton layer. Allow to dry completely before putting your protector, sheets, and bedding back on your bed. Do not machine wash or dry clean your topper cover.